Coevolution of white matter hyperintensities and cognition in the elderly.

ABSTRACT:

Objective

To investigate the effects of baseline white matter hyperintensity (WMH) and rates of WMH extension and emergence on rate of change in cognition (episodic memory and executive function).

Methods

A total of 150 individuals including cognitively normal elderly individuals and those with Alzheimer disease and mild cognitive impairment completed serial episodic memory and executive function evaluations and serial MRI scans sufficient for longitudinal measurement of WMH (mean delay 4.0 years). Incident WMH voxels were categorized as extended (baseline WMH that grew larger) or emergent (newly formed WMH). We used a stepwise regression approach to investigate the effects of baseline WMH and rates of WMH extension and emergence on rate of change in cognition (episodic memo

SUBMITTER: Maillard P 

PROVIDER: S-EPMC3405254 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature