Founder BRCA1/2 mutations in the Europe: implications for hereditary breast-ovarian cancer prevention and control.

ABSTRACT: Detection of mutations in hereditary breast and ovarian cancer-related BRCA1 and BRCA2 genes is an effective method of cancer prevention and early detection. Different ethnic and geographical regions have different BRCA1 and BRCA2 mutation spectrum and prevalence. Along with the emerging targeted therapy, demand and uptake for rapid BRCA1/2 mutations testing will increase in a near future. However, current patients selection and genetic testing strategies in most countries impose significant lag in this practice. The knowledge of the genetic structure of particular populations is important for the developing of effective screening protocol and may provide more efficient approach for the individualization of genetic testing. Elucidating of founder effect in BRCA1/2 genes can have an impact

SUBMITTER: Janavicius R 

PROVIDER: S-EPMC3405339 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature