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Recent advances and novel agents for gastrointestinal stromal tumor (GIST).

ABSTRACT: The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative. GIST research and clinical care now represent a paradigm of translating discoveries in the molecular pathogenesis of cancer into highly effective targeted therapies that selectively inhibit etiologic "driver" pathways, leading to dramatically improved clinical outcomes. A series of investigations and trials are underway to develop novel and effective ways to treat patients with GIST. In this review, we discuss the highlights of recent advances and novel agents for GIST therapy.

SUBMITTER: Lamba G 

PROVIDER: S-EPMC3405472 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Recent advances and novel agents for gastrointestinal stromal tumor (GIST).

Lamba Gurpreet G   Ambrale Samir S   Lee Byung B   Gupta Ridhi R   Rafiyath Shamudheen M SM   Liu Delong D  

Journal of hematology & oncology 20120508

The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomyoma, and leiomyosarcoma are typically CD117-negative. GIST research and clinical care now represent a paradigm of translating discoveries in the molecular pathogenesis of cancer into highly effective targeted therapies that selectively inhibit etiologic "driver" pathways, leading to dramati  ...[more]

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