An integrated regulatory network reveals pervasive cross-regulation among transcription and splicing factors.

ABSTRACT: Traditionally the gene expression pathway has been regarded as being comprised of independent steps, from RNA transcription to protein translation. To date there is increasing evidence of coupling between the different processes of the pathway, specifically between transcription and splicing. To study the interplay between these processes we derived a transcription-splicing integrated network. The nodes of the network included experimentally verified human proteins belonging to three groups of regulators: transcription factors, splicing factors and kinases. The nodes were wired by instances of predicted transcriptional and alternative splicing regulation. Analysis of the network indicated a pervasive cross-regulation among the nodes; specifically, splicing factors are significantly more co

SUBMITTER: Kosti I 

PROVIDER: S-EPMC3405991 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature