Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation.

ABSTRACT: Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to equal the gene expression in females, which have two X-chromosomes. Dosage compensation is mediated by the Male-Specific Lethal (MSL) histone acetyltransferase complex. Five core components of the MSL complex were identified by genetic screens for genes that are specifically required for male viability and are dispensable for females. However, because dosage compensation must interface with the general transcriptional machinery, it is likely that identifying additional regulators that are not strictly male-specific will be key to understan

SUBMITTER: Larschan E 

PROVIDER: S-EPMC3405997 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature