Prenatal and postnatal maternal stress and wheeze in urban children: effect of maternal sensitization.

ABSTRACT:

Rationale

Critical periods for programming early wheeze risk may include pregnancy and infancy. Effects of timing remain poorly understood.

Objectives

Associations among prenatal and postnatal maternal stress and children's wheeze were prospectively examined in 653 families. Effect modification by maternal sensitization was also examined.

Methods

Stress was indexed by a maternal negative life events (NLEs) score (range, 0-9) ascertained during pregnancy and between 1 and 2 years postpartum. Mothers reported child wheeze every 3 months up to age 2 years. Relationships of prenatal and postnatal maternal NLEs with repeated wheeze (≥2 episodes) were examined using logistic regression adjusting for covariates. Penalized splines were implemented to explore possible nonlinea

SUBMITTER: Chiu YH 

PROVIDER: S-EPMC3406080 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature