Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children.

ABSTRACT:

Rationale

Vitamin D insufficiency (a serum 25(OH)D <30 ng/ml) has been associated with severe asthma exacerbations, but this could be explained by underlying racial ancestry or disease severity. Little is known about vitamin D and asthma in Puerto Ricans.

Objectives

To examine whether vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, and time outdoors.

Methods

A cross-sectional study was conducted of 560 children ages 6-14 years with (n = 287) and without (n = 273) asthma in San Juan, Puerto Rico. We measured plasma vitamin D and estimated the percentage of African racial ancestry among participants using genome-wide genotypic data. We tested whether vitamin D insufficiency is asso

SUBMITTER: Brehm JM 

PROVIDER: S-EPMC3406083 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature