Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention.

ABSTRACT: Carcinoma of the stomach is still the second most common cause of cancer death worldwide, although the incidence and mortality have fallen dramatically over the last 50 years in many regions. The incidence of gastric cancer varies in different parts of the world and among various ethnic groups. Despite advances in diagnosis and treatment, the 5-year survival rate of stomach cancer is only 20 per cent. Stomach cancer can be classified into intestinal and diffuse types based on epidemiological and clinicopathological features. The etiology of gastric cancer is multifactorial and includes both dietary and nondietary factors. The major diet-related risk factors implicated in stomach cancer development include high content of nitrates and high salt intake. Accumulating evidence has implicated t

SUBMITTER: Nagini S 

PROVIDER: S-EPMC3406280 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature