Humoral immune responses to Plasmodium falciparum among HIV-1-infected Kenyan adults.

ABSTRACT:

Introduction

Humoral immune responses play a pivotal role in naturally acquired immunity to malaria. Understanding which humoral responses are impaired among individuals at higher risk for malaria may improve our understanding of malaria immune control and contribute to vaccine development.

Methods

We compared humoral responses with 483 Plasmodium falciparum antigens between adults in, Kisumu (high, year-long malaria transmission leading to partial immunity), and adults in Kisii (low, seasonal malaria transmission). Then within each site, we compared malaria-specific humoral responses between those at higher risk for malaria (CD4(+) ≤500) and those at lower risk for malaria (CD4(+) >500). A protein microarray chip containing 483 P. falciparum antigens and 71 HIV antigens was

SUBMITTER: Nnedu ON 

PROVIDER: S-EPMC3406934 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature