Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.

ABSTRACT:

Background

Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation. Due to tight coordination between ribosome biogenesis and cell proliferation, transcription of rRNA and stable maintenance of rDNA clusters are thought to be under intricate control by intercalated mechanisms, particularly at the epigenetic level.

Methods and results

Here we identify the nucleolar protein Myb-binding protein 1a (Mybbp1a) as a novel negative regulator of rRNA expression. Suppression of rDNA transcription by Mybbp1a was linked to promoter regulation as illustrated by its binding to the chromatin around the hypermethylated, inactive rDNA gene promoters. Our data further showed that downregulation o

SUBMITTER: Tan BC 

PROVIDER: S-EPMC3407492 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature