Ontology highlight
ABSTRACT:
SUBMITTER: Schon EA
PROVIDER: S-EPMC3407575 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Neuron 20110601 6
Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the nervous system whose underlying mechanisms of cell death remain unknown. Defects in mitochondrial respiration had previously been proposed to contribute to the occurrence of many, if not all, of the most common neurodegenerative disorders. However, the discovery of genes mutated in hereditary forms of these enigmatic diseases has additionally suggested defects in mitochondrial dynamics. Such disturbances can le ...[more]