Association of an NFKB1 intron SNP (rs4648068) with gastric cancer patients in the Han Chinese population.

ABSTRACT:

Background

Hyperactivation of nuclear factor-κB (NF-κB) is associated with various types of tumors. This study investigated the susceptibility of the rs4648068 A/G genotype in the intron region of NFKB1 to gastric cancer and the association of this polymorphism with clinicopathologic variables in gastric cancer patients.

Methods

A hospital-based case-control study of 248 gastric cancer patients and 192 control individuals was conducted in Fudan University Shanghai Cancer Center (Shanghai, China). Single nucleotide polymorphism (SNP) rs4648068 genotype in NFKB1 from blood samples of a total of 440 people was analyzed by polymerase chain reaction-based genotyping.

Results

The frequencies of the AA, AG, and GG genotypes of the rs4648068 polymorphism were 31.5%, 47.2%, an

SUBMITTER: Lu R 

PROVIDER: S-EPMC3407756 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature