Palladium-catalyzed asymmetric allylic alkylation of electron-deficient pyrroles with meso electrophiles.

ABSTRACT: Pyrroles can serve as competent nucleophiles with meso electrophiles in the Pd-catalyzed asymmetric allylic alkylation. The products from this transformation were obtained as a single regio- and diastereomer in high yield and enantiopurity. A nitropyrrole-containing nucleoside analogue was synthesized in seven steps to demonstrate the synthetic utility of this transformation.

SUBMITTER: Trost BM 

PROVIDER: S-EPMC3407807 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature