Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids.

ABSTRACT:

Objective

SNPs identified from genome-wide association studies associate with lipid risk markers of cardiovascular disease. This study investigated whether these SNPs altered the plasma lipid response to diet in the 'RISCK' study cohort.

Methods

Participants (n=490) from a dietary intervention to lower saturated fat by replacement with carbohydrate or monounsaturated fat, were genotyped for 39 lipid-associated SNPs. The association of each individual SNP, and of the SNPs combined (using genetic predisposition scores), with plasma lipid concentrations was assessed at baseline, and on change in response to 24 weeks on diets.

Results

The associations between SNPs and lipid concentrations were directionally consistent with previous findings. The genetic predisposition sco

SUBMITTER: Walker CG 

PROVIDER: S-EPMC3407860 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature