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4-Methylenesterols from a sponge Theonella swinhoei.

ABSTRACT: Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.

SUBMITTER: Guo JK 

PROVIDER: S-EPMC3407929 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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4-Methylenesterols from a sponge Theonella swinhoei.

Guo Jheng-Kun JK   Chiang Ching-Ying CY   Lu Mei-Chin MC   Chang Wen-Been WB   Su Jui-Hsin JH  

Marine drugs 20120719 7

Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines. ...[more]

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