Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.

ABSTRACT:

Objectives/hypothesis

Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with the risk of several cancers, including breast (rs1562430), prostate (rs1447295), and colon (rs6983267). A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of this chromosomal region in relation to the risk of sporadic PTC.

Study design

Case-control study.

Methods

We evaluated 157 tag SNPs in the 8q24 chromosomal region between 120.91 Mb and 128.78 Mb (including rs1562430, rs1447295, and rs6983267) in a case-control study of 344 PTC cases and 452 age and gender frequency-matched controls. We used logistic regression to estimate odd

SUBMITTER: Neta G 

PROVIDER: S-EPMC3408055 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature