Transcriptional network structure has little effect on the rate of regulatory evolution in yeast.

ABSTRACT: Studies in evolutionary developmental biology suggest that the structure of genetic pathways may bias the fixation of natural variation toward particular nodes in these pathways. In an attempt to test this trend genome wide, we integrated several previously published data sets to examine whether the position of genes in the whole-genome transcriptional network of Saccharomyces cerevisiae is associated with the amount of cis-regulatory expression divergence between S. cerevisiae and its sibling species Saccharomyces paradoxus. We find little evidence for an association between connectivity and divergence in the global network that combines data from multiple conditions. However, relationships between connectivity and divergence are apparent in some of the smaller subnetworks. Despite a slig

SUBMITTER: Kopp A 

PROVIDER: S-EPMC3408065 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature