Transcriptomic biomarkers for the accurate diagnosis of myocarditis.

ABSTRACT:

Background

Lymphocytic myocarditis is a clinically important condition that is difficult to diagnose and distinguish. We hypothesized that the transcriptome obtained from an endomyocardial biopsy would yield clinically relevant and accurate molecular signatures.

Methods and results

Microarray analysis was performed on samples from patients with histologically proven lymphocytic myocarditis (n=16) and idiopathic dilated cardiomyopathy (n=32) to develop accurate diagnostic transcriptome-based biomarkers using multiple classification algorithms. We identified 9878 differentially expressed genes in lymphocytic myocarditis versus idiopathic dilated cardiomyopathy (fold change >1.2; false discovery rate <5%) from which a transcriptome-based biomarker containing 62 genes was identi

SUBMITTER: Heidecker B 

PROVIDER: S-EPMC3408077 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature