Association of HLA genes with clinical outcomes of ANCA-associated vasculitis.

ABSTRACT:

Background and objectives

The HLA system plays a central role in the distinction between self antigens and non-self antigens. This study aimed to investigate the association between HLA genes and the outcomes of patients with ANCA-associated vasculitis (AAV).

Design, setting, participants, & measurements

This study recruited 152 consecutive Chinese patients with AAV. The predictive value of the HLA alleles for renal outcome, response to treatment, and all-cause mortality were analyzed.

Results

The proportion of patients with treatment failure was significantly higher in DRB1*0405-positive patients than in DRB1*0405-negative patients (41.7% versus 12.9%; P=0.008; corrected P=0.02). After adjusting for the other potential predictors, DRB1*0405 was still an independent p

SUBMITTER: Chang DY 

PROVIDER: S-EPMC3408128 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature