Transcriptome-based identification of antioxidative gene expression after fish oil supplementation in normo- and dyslipidemic men.

ABSTRACT:

Background

The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), especially in dyslipidemic subjects with a high risk of cardiovascular disease, are widely described in the literature. A lot of effects of n-3 PUFAs and their oxidized metabolites are triggered by regulating the expression of genes. Currently, it is uncertain if the administration of n-3 PUFAs results in different expression changes of genes related to antioxidative mechanisms in normo- and dyslipidemic subjects, which may partly explain their cardioprotective effects. The aim of this study was to investigate the effects of n-3 PUFA supplementation on expression changes of genes involved in oxidative processes.

Methods

Ten normo- and ten dyslipidemic men were supplemented for twelve weeks

SUBMITTER: Schmidt S 

PROVIDER: S-EPMC3408332 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature