Ontology highlight
ABSTRACT:
SUBMITTER: Paveley RA
PROVIDER: S-EPMC3409125 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PLoS neglected tropical diseases 20120731 7
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics. To discover new leads we designed an automated label-free, high content-based, high throughput screen (HTS) to assess drug-induced effects on in vitro cultured larvae (schistosomula) using bright-field imaging. Automatic image analysis and Bayesian prediction models define morphological ...[more]