The natural history of class I primate alcohol dehydrogenases includes gene duplication, gene loss, and gene conversion.

ABSTRACT:

Background

Gene duplication is a source of molecular innovation throughout evolution. However, even with massive amounts of genome sequence data, correlating gene duplication with speciation and other events in natural history can be difficult. This is especially true in its most interesting cases, where rapid and multiple duplications are likely to reflect adaptation to rapidly changing environments and life styles. This may be so for Class I of alcohol dehydrogenases (ADH1s), where multiple duplications occurred in primate lineages in Old and New World monkeys (OWMs and NWMs) and hominoids.

Methodology/principal findings

To build a preferred model for the natural history of ADH1s, we determined the sequences of nine new ADH1 genes, finding for the first time multiple paral

SUBMITTER: Carrigan MA 

PROVIDER: S-EPMC3409193 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature