A diverse range of gene products are effectors of the type I interferon antiviral response.

ABSTRACT: The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified since their discovery more than 25 years ago, only a few have been characterized with respect to antiviral activity. For most ISG products, little is known about their antiviral potential, their target specificity and their mechanisms of action. Using an overexpression screening approach, here we show that different viruses are targeted by unique sets of ISGs. We find that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities. To conduct the screen, more than 380 human ISGs were tested for their ab

SUBMITTER: Schoggins JW 

PROVIDER: S-EPMC3409588 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature