Vocal acoustic biomarkers of depression severity and treatment response.

ABSTRACT:

Background

Valid, reliable biomarkers of depression severity and treatment response would provide new targets for clinical research. Noticeable differences in speech production between depressed and nondepressed patients have been suggested as a potential biomarker.

Methods

One hundred five adults with major depression were recruited into a 4-week, randomized, double-blind, placebo-controlled research methodology study. An exploratory objective of the study was to evaluate the generalizability and repeatability of prior study results indicating vocal acoustic properties in speech may serve as biomarkers for depression severity and response to treatment. Speech samples, collected at baseline and study end point using an automated telephone system, were analyzed as a function

SUBMITTER: Mundt JC 

PROVIDER: S-EPMC3409931 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature