Acute free fatty acid elevation eliminates endurance training effect on insulin sensitivity.

ABSTRACT:

Context

Both training and normal body mass index are associated with high insulin sensitivity, but the mechanism may be different.

Objective

The aim of the study was to examine whether lean trained humans may be protected from acute free fatty acid (FFA)-induced insulin resistance compared with lean sedentary humans.

Design and setting

We conducted an interventional trial using either a 6-h lipid (20% Intralipid at 90 ml/h) or glycerol (2.25 g/100 ml at 90 ml/h) infusion along with a concurrent hyperinsulinemic-euglycemic clamp and serial muscle biopsies (0, 120, 360 min) at a clinical research unit at the University of Minnesota.

Patients or participants

The study included lean endurance-trained (n = 14) and sedentary (n = 14) individuals matched for age, gend

SUBMITTER: Chow LS 

PROVIDER: S-EPMC3410274 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature