TP53 genetic alterations in Arab breast cancer patients: Novel mutations, pattern and distribution.

ABSTRACT: Breast cancer remains a worldwide public health concern. The incidence and mortality of breast cancer varies significantly in ethnically and geographically distinct populations. In the Kingdom of Saudi Arabia (KSA) breast cancer has shown an increase in incidence and is characterized by early onset and aggressiveness. The tumor suppressor TP53 gene is a crucial genetic factor that plays a significant role in breast carcinogenesis. Furthermore, studies have shown a correlation between certain p53 mutations and response to therapy in breast cancer. In the present study, TP53 mutations were identified by direct sequencing of the gene (exons 4-9) from 119 breast cancer tissues. The prevalence of TP53 mutations in Arab breast cancer patients living in the KSA is among the highest in the world (

SUBMITTER: Al-Qasem AJ 

PROVIDER: S-EPMC3410563 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature