A molecular characterization of the choroid plexus and stress-induced gene regulation.

ABSTRACT: The role of the choroid plexus (CP) in brain homeostasis is being increasingly recognized and recent studies suggest that the CP has a more important role in physiological and pathological brain functions than currently appreciated. To obtain additional insight on the CP function, we performed a proteomics and transcriptomics characterization employing a combination of high resolution tandem mass spectrometry and gene expression analyses in normal rodent brain. Using multiple protein fractionation approaches, we identified 1400 CP proteins in adult CP. Microarray-based comparison of CP gene expression with the kidney, cortex and hippocampus showed significant overlap between the CP and the kidney. CP gene profiles were validated by in situ hybridization analysis of several target genes inc

SUBMITTER: Sathyanesan M 

PROVIDER: S-EPMC3410626 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature