Genetic factors for choroidal neovascularization associated with high myopia.

ABSTRACT:

Purpose

Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degeneration (AMD) are related to myopic CNV.

Methods

We conducted a case-control study, including 71 cases with myopic CNV and 196 myopic controls without CNV, from Creteil and Toulouse, France, and Boston, MA. Single nucleotide polymorphisms (SNPs) from 15 genes reported to be related to AMD were selected for association testing in this study.

Results

In univariate analysis, the rs10033900 SNP located in CFI was associated with myopic CNV (P = 0.0011), and a

SUBMITTER: Leveziel N 

PROVIDER: S-EPMC3410690 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature