Whole genome sequencing analysis of Plasmodium vivax using whole genome capture.

ABSTRACT:

Background

Malaria caused by Plasmodium vivax is an experimentally neglected severe disease with a substantial burden on human health. Because of technical limitations, little is known about the biology of this important human pathogen. Whole genome analysis methods on patient-derived material are thus likely to have a substantial impact on our understanding of P. vivax pathogenesis and epidemiology. For example, it will allow study of the evolution and population biology of the parasite, allow parasite transmission patterns to be characterized, and may facilitate the identification of new drug resistance genes. Because parasitemias are typically low and the parasite cannot be readily cultured, on-site leukocyte depletion of blood samples is typically needed to remove human DNA tha

SUBMITTER: Bright AT 

PROVIDER: S-EPMC3410760 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature