Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes.

ABSTRACT:

Background

Telomeres are nucleoprotein complexes at the end of linear eukaryotic chromosomes which maintain the genome integrity by regulating telomere length, preventing recombination and end to end fusion events. Multiple proteins associate with telomeres and function in concert to carry out these functions. Rap1 interacting factor 1 (Rif1), was identified as a protein involved in telomere length regulation in yeast. Rif1 is conserved upto mammals but its function has diversified from telomere length regulation to maintenance of genome integrity.

Results

We have carried out detailed bioinformatic analyses and identified Rif1 homologues in 92 organisms from yeast to human. We identified Rif1 homologues in Drosophila melanogaster, even though fly telomeres are maintained by

SUBMITTER: Sreesankar E 

PROVIDER: S-EPMC3410773 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature