MiREvo: an integrative microRNA evolutionary analysis platform for next-generation sequencing experiments.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small (~19-24nt) non-coding RNAs that play important roles in various biological processes. To date, the next-generation sequencing (NGS) technology has been widely used to discover miRNAs in plants and animals. Although evolutionary analysis is important to reveal the functional dynamics of miRNAs, few computational tools have been developed to analyze the evolution of miRNA sequence and expression across species, especially the newly emerged ones,

Results

We developed miREvo, an integrated software platform with a graphical user interface (GUI), to process deep-sequencing data of small RNAs and to analyze miRNA sequence and expression evolution based on the multiple-species whole genome alignments (WGAs). Three major features are provided

SUBMITTER: Wen M 

PROVIDER: S-EPMC3410788 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature