Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly.

ABSTRACT: The successful completion of meiosis is essential for all sexually reproducing organisms. The synaptonemal complex (SC) is a large proteinaceous structure that holds together homologous chromosomes during meiosis, providing the structural framework for meiotic recombination and crossover formation. Errors in SC formation are associated with infertility, recurrent miscarriage and aneuploidy. The current lack of molecular information about the dynamic process of SC assembly severely restricts our understanding of its function in meiosis. Here, we provide the first biochemical and structural analysis of an SC protein component and propose a structural basis for its function in SC assembly. We show that human SC proteins SYCE2 and TEX12 form a highly stable, constitutive complex, and define th

SUBMITTER: Davies OR 

PROVIDER: S-EPMC3411106 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature