Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development.

ABSTRACT: The ability to stop producing or replacing cells at the appropriate time is essential, as uncontrolled growth can lead to loss of function and even cancer. Tightly regulated mechanisms coordinate the growth of stem cell progeny with the patterning needs of the host organism. Despite the importance of proper termination during regeneration, cell turnover, and embryonic development, very little is known about how tissues determine when patterning is complete during these processes. Using planarian flatworms, we show that the planar cell polarity (PCP) pathway is required to stop the growth of neural tissue. Although traditionally studied as regulators of tissue polarity, we found that loss of the PCP genes Vangl2, DAAM1, and ROCK by RNA interference (individually or together) resulted in sup

SUBMITTER: Beane WS 

PROVIDER: S-EPMC3411359 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature