Discordant antibody and cellular responses to Pneumocystis major surface glycoprotein variants in mice.

ABSTRACT:

Background

The major surface glycoprotein (Msg) of Pneumocystis is encoded by approximately 50 to 80 unique but related genes. Msg diversity may represent a mechanism for immune escape from host T cell responses. We examined splenic T cell proliferative and cytokine as well as serum antibody responses to recombinant and native Pneumocystis antigens in immunized or Pneumocystis-infected mice. In addition, immune responses were examined in 5 healthy humans.

Results

Proliferative responses to each of two recombinant Msg variant proteins were seen in mice immunized with either recombinant protein, but no proliferation to these antigens was seen in mice immunized with crude Pneumocystis antigens or in mice that had cleared infection, although the latter animals demonstrated proli

SUBMITTER: Bishop LR 

PROVIDER: S-EPMC3411419 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature