Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice.

ABSTRACT:

Background

Numerous transgenic models have been generated to study breast cancer. However, despite many advantages, traditional transgenic models for breast cancer are also burdened with difficulties in early detection and longitudinal observation of transgene-induced tumours, which in most cases are randomly located and occur at various time points. Methods such as palpation followed by mechanical measurement of the tumours are of limited value in transgenic models. There is a crucial need for making these previously generated models suitable for modern methods of tumour visualisation and monitoring, e.g. by bioluminescence-based techniques. This approach was successfully used in the current study.

Results

A new mouse strain (MMTV-Luc2 mice) expressing Luc2 luciferase prima

SUBMITTER: Zagozdzon AM 

PROVIDER: S-EPMC3411433 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature