Chimeric Hepatitis B core antigen virus-like particles displaying the envelope domain III of dengue virus type 2.

ABSTRACT:

Background

Dengue is a global public health problem for which no drug or vaccine is available. Currently, there is increasing interest in developing non-replicating dengue vaccines based on a discrete antigenic domain of the major structural protein of dengue viruses (DENVs), known as envelope domain III (EDIII). The use of bio-nanoparticles consisting of recombinant viral structural polypeptides, better known as virus-like particles (VLPs), has emerged as a potential platform technology for vaccine development. This work explores the feasibility of developing nanoparticles based on E. coli-expressed recombinant Hepatitis B virus core antigen (HBcAg) designed to display EDIII moiety of DENV on the surface.

Findings

We designed a synthetic gene construct encoding HBcAg contai

SUBMITTER: Arora U 

PROVIDER: S-EPMC3411447 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature