The modular nature of dendritic cell responses to commensal and pathogenic fungi.

ABSTRACT: The type of adaptive immune response following host-fungi interaction is largely determined at the level of the antigen-presenting cells, and in particular by dendritic cells (DCs). The extent to which transcriptional regulatory events determine the decision making process in DCs is still an open question. By applying the highly structured DC-ATLAS pathways to analyze DC responses, we classified the various stimuli by revealing the modular nature of the different transcriptional programs governing the recognition of either pathogenic or commensal fungi. Through comparison of the network parts affected by DC stimulation with fungal cells and purified single agonists, we could determine the contribution of each receptor during the recognition process. We observed that initial recognition of

SUBMITTER: Rizzetto L 

PROVIDER: S-EPMC3411757 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature