Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms.

ABSTRACT:

Objective

Arterial stiffness decreases with weight loss in overweight/obese young adults. We aimed to determine the mechanisms by which this occurs.

Methods

We evaluated carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) in 344 young adults (23% male, BMI 25-40 kg/m(2)) at baseline, 6, and 12 months in a behavioral weight loss intervention. Linear mixed models were used to evaluate associations between weight loss and arterial stiffness and to examine whether improvements in obesity-related factors explained these associations.

Results

At 6 months (7% mean weight loss), there was a significant median decrease of 47.5 cm/s in cfPWV (p < 0.0001) and a mean decrease of 11.7 cm/s in baPWV (p = 0.049). At 12 months (6% mean weight lo

SUBMITTER: Cooper JN 

PROVIDER: S-EPMC3411893 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature