Characterization of two neuronal subclasses through constellation pharmacology.

ABSTRACT: Different types of neurons diverge in function because they express their own unique set or constellation of signaling molecules, including receptors and ion channels that work in concert. We describe an approach to identify functionally divergent neurons within a large, heterogeneous neuronal population while simultaneously investigating specific isoforms of signaling molecules expressed in each. In this study we characterized two subclasses of menthol-sensitive neurons from cultures of dissociated mouse dorsal-root ganglia. Although these neurons represent a small fraction of the dorsal-root ganglia neuronal population, we were able to identify them and investigate the cell-specific constellations of ion channels and receptors functionally expressed in each subclass, using a panel of sel

SUBMITTER: Teichert RW 

PROVIDER: S-EPMC3411979 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature