Ontology highlight
ABSTRACT:
SUBMITTER: Majumdar S
PROVIDER: S-EPMC3412067 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20120716 14
3-Iodobenzoylnaltrexamide 1 (IBNtxA) is a potent analgesic acting through a novel receptor target that lack many side-effects of traditional opiates composed, in part, of exon 11-associated truncated six transmembrane domain MOR-1 (6TM/E11) splice variants. To better understand the SAR of this drug target, a number of 4,5-epoxymorphinan analogues were synthesized. Results show the importance of a free 3-phenolic group, a phenyl ring at the 6 position, an iodine at the 3'or 4' position of the phe ...[more]