Defining new criteria for selection of cell-based intestinal models using publicly available databases.

ABSTRACT:

Background

The criteria for choosing relevant cell lines among a vast panel of available intestinal-derived lines exhibiting a wide range of functional properties are still ill-defined. The objective of this study was, therefore, to establish objective criteria for choosing relevant cell lines to assess their appropriateness as tumor models as well as for drug absorption studies.

Results

We made use of publicly available expression signatures and cell based functional assays to delineate differences between various intestinal colon carcinoma cell lines and normal intestinal epithelium. We have compared a panel of intestinal cell lines with patient-derived normal and tumor epithelium and classified them according to traits relating to oncogenic pathway activity, epithelial-me

SUBMITTER: Christensen J 

PROVIDER: S-EPMC3412164 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature