Ontology highlight
ABSTRACT:
SUBMITTER: Gharavi AG
PROVIDER: S-EPMC3412515 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Nature genetics 20110313 4
We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. We identified three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance (P v ...[more]