Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.

ABSTRACT:

Rationale

The type I subclass of coronins, a family of actin-binding proteins, regulates various actin-dependent cellular processes, including migration. However, the existence and role of coronins in vascular smooth muscle cell (VSMC) migration has yet to be determined.

Objective

The goal of the present study was to define the mechanism by which coronins regulate platelet-derived growth factor (PDGF)-induced VSMC migration.

Methods and results

Coronin 1B (Coro1B) and 1C (Coro1C) were both found to be expressed in VSMCs at the mRNA and protein levels. Downregulation of Coro1B by siRNA increases PDGF-induced migration, while downregulation of Coro1C has no effect. We confirmed through kymograph analysis that the Coro1B-downregulation-mediated increase in migration is d

SUBMITTER: Williams HC 

PROVIDER: S-EPMC3412545 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature