TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer.

ABSTRACT:

Motivation

Triple-negative breast cancer (TNBC) is a heterogeneous breast cancer group, and identification of molecular subtypes is essential for understanding the biological characteristics and clinical behaviors of TNBC as well as for developing personalized treatments. Based on 3,247 gene expression profiles from 21 breast cancer data sets, we discovered six TNBC subtypes from 587 TNBC samples with unique gene expression patterns and ontologies. Cell line models representing each of the TNBC subtypes also displayed different sensitivities to targeted therapeutic agents. Classification of TNBC into subtypes will advance further genomic research and clinical applications.

Result

We developed a web-based subtyping tool TNBCtype for candidate TNBC samples using our gene expre

SUBMITTER: Chen X 

PROVIDER: S-EPMC3412597 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature