IKKβ-I-κBɛ-c-Rel/p50: a new axis of NF-κB activation in lung epithelial cells.

ABSTRACT: Cigarette smoke (CS), a major risk factor for developing lung cancer, is known to activate transcriptional activator nuclear factor kappa B (NF-κB). However, the underlying mechanism of this activation remains unclear because of conflicting reports. As NF-κB has a pivotal role in the generation and maintenance of malignancies, efforts were targeted towards understanding its activation mechanism using both ex vivo and in vivo studies. The results show that CS-induced NF-κB activation mechanism is different from that of other pro-inflammatory signals such as lipopolysaccharide (LPS). The NF-κB dimer that translocates to the nucleus upon stimulation with CS is predominantly composed of c-Rel/p50 and this translocation involves degradation of I-κBɛ and not I-κBα. This degradation of I-κBɛ depe

SUBMITTER: Maity PC 

PROVIDER: S-EPMC3412642 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature