Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides.

ABSTRACT: Cementum is the outer-, mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated, may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix, we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as ameloge

SUBMITTER: Gungormus M 

PROVIDER: S-EPMC3412665 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature