Prediction of incident heart failure in general practice: the Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Background

A simple and effective heart failure (HF) risk score would facilitate the primary prevention and early diagnosis of HF in general practice. We examined the external validity of existing HF risk scores, optimized a 10-year HF risk function, and examined the incremental value of several biomarkers, including N-terminal pro-brain natriuretic peptide.

Methods and results

During 15.5 years (210 102 person-years of follow-up), 1487 HF events were recorded among 13 555 members of the biethnic Atherosclerosis Risk in Communities (ARIC) Study cohort. The area under curve from the Framingham-published, Framingham-recalibrated, Health ABC HF recalibrated, and ARIC risk scores were 0.610, 0.762, 0.783, and 0.797, respectively. On addition of N-terminal pro-brain natriuretic p

SUBMITTER: Agarwal SK 

PROVIDER: S-EPMC3412686 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature