JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny.

ABSTRACT:

Background

It has been reported that the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway regulates erythropoietin (EPO)-induced survival, proliferation, and maturation of early erythroid progenitors. Erythroid cell proliferation and survival have also been related to activation of the JAK-STAT pathway. The goal of this study was to observe the function of EPO activation of JAK-STAT and PI3K/AKT pathways in the development of erythroid progenitors from hematopoietic CD34+ progenitor cells, as well as to distinguish early EPO target genes in human erythroid progenitors during ontogeny.

Methods

Hematopoietic CD34+ progenitor cells, isolated from fetal and adult hematopoietic tissues, were differentiated into erythroid progenitor cells. We have used microarray analysi

SUBMITTER: Cokic VP 

PROVIDER: S-EPMC3412720 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature