Association between FGFR1OP2/wit3.0 polymorphisms and residual ridge resorption of mandible in Korean population.

ABSTRACT:

Background

A previous study on the genetic association between single nucleotide polymorphisms in FGFR1OP2/wit3.0 and the long term atrophy of edentulous mandible hypothesized that the excessive jawbone atrophy after dental extraction may be associated with abnormal oral mucosa contraction induced by the FGFR1OP2/wit 3.0 gene. It was reported that the minor allele of rs840869 or rs859024 in FGFR1OP2/wit3.0 was associated with the excessive atrophy of edentulous mandible. The present study represents an attempt to replicate the results of this previous study and to examine the genetic association between polymorphisms in FGFR1OP2 and residual ridge resorption of mandible in a Korean population.

Methodology/principal findings

134 subjects (70.46 ± 9.02 years) with partially or

SUBMITTER: Kim JH 

PROVIDER: S-EPMC3412816 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature