MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells.

ABSTRACT:

Background

Oxidative injury to retinal pigment epithelium (RPE) and retinal photoreceptors has been linked to a number of retinal diseases, including age-related macular degeneration (AMD). Reactive oxygen species (ROS)-mediated gene expression has been extensively studied at transcriptional levels. Also, the post-transcriptional control of gene expression at the level of translational regulation has been recently reported. However, the microRNA (miRNA/miR)-mediated post-transcriptional regulation in human RPE cells has not been thoroughly looked at. Increasing evidence points to a potential role of miRNAs in diverse physiological processes.

Methodology/principal findings

We demonstrated for the first time in a human retinal pigment epithelial cell line (ARPE-19) that the po

SUBMITTER: Haque R 

PROVIDER: S-EPMC3412823 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature